Intracellular Trafficking and Function of a Recycling Receptor Which Prolongs the Serum Half-Life of Novel Therapeutic Proteins

Grant number: LP130100531 | Funding period: 2013 - 2017

Completed

Abstract

The life span of recombinant engineered proteins for therapeutic use is a critical factor in their effectiveness, ease of clinical application and cost. This project will exploit interactions with a natural receptor, which prolongs the lifespan of serum proteins, to enhance survival of therapeutic engineered proteins.

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Signal dependent transport of a membrane cargo from early endosomes to recycling endosomes

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University of Melbourne Researchers

Paul Gleeson